A CFD Investigation on the Aerosol Drug Delivery in the Mouth–Throat Airway Using a Pressurized Metered-Dose Inhaler Device

Inhalation therapy involving a pressurized metered-dose inhaler (pMDI) is one of the most commonly used and effective treatment methods for patients with asthma. The purpose this study was to develop computational fluid dynamics (CFD) model characterize aerosol flow issued from pMDI into simulated mouth–throat geometry. effects air rate cone angle were analyzed in detail. behaviour multiphase initiated at actuation nozzle extended through airway based on Eulerian-Lagrangian discrete phase model, k-? applied turbulency. We validated our against published experimental measurements cover hydrodynamic aspect study. recirculation we observed 90° bend inside resulted selective retention larger diameter particles, patterns correlated drug deposition behaviour. Enhancing rates up three times reduced aerodynamic particle diameters 20%. also that, as increased, mouth increased; an 8° best lowest deposition.